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DANRE:TAL1

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Contents

Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) tal1 (synonyms: scl, tal-1)
Protein Name(s) T-cell acute lymphocytic leukemia protein 1 homolog

TAL-1 Stem cell protein zSCL

External Links
UniProt O93507
EMBL AF038873
AF045432
EF488003
EF488004
AL592495
BX664601
BX322568
BX322568
BX664601
BC068324
IPI IPI00493592
IPI00972632
RefSeq NP_998402.1
UniGene Dr.75812
ProteinModelPortal O93507
STRING O93507
Ensembl ENSDART00000083063
GeneID 30766
KEGG dre:30766
CTD 6886
ZFIN ZDB-GENE-980526-501
eggNOG fiNOG05366
GeneTree ENSGT00590000082747
HOVERGEN HBG005018
InParanoid O93507
OrthoDB EOG4TMR2R
ArrayExpress O93507
Bgee O93507
GO GO:0005634
GO:0003677
GO:0001525
GO:0048844
GO:0060216
GO:0035050
GO:0060214
GO:0003007
GO:0060217
GO:0060218
GO:0048368
GO:0048823
GO:0045603
GO:0006355
GO:0030878
GO:0006351
GO:0001570
InterPro IPR011598
Gene3D G3DSA:4.10.280.10
KO K09068
Pfam PF00010
SMART SM00353
SUPFAM SSF47459
PROSITE PS50888

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001525

angiogenesis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0037

P

Seeded From UniProt

GO:0001525

angiogenesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0001525

angiogenesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050207-1

P

Seeded From UniProt

GO:0001525

angiogenesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050207-2

P

Seeded From UniProt

GO:0001568

blood vessel development

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

GO:0001568

blood vessel development

PMID:16968815[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

GO:0001570

vasculogenesis

PMID:9499398[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0001570

vasculogenesis

PMID:9670018[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0003007

heart morphogenesis

PMID:17681136[6]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-050622-14

P

Seeded From UniProt

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded From UniProt

GO:0003677

DNA binding

PMID:16210319[7]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16210319[7]

IC: Inferred by Curator

GO:0003677

C

Seeded From UniProt

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

Seeded From UniProt

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

Seeded From UniProt

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

Seeded From UniProt

GO:0030097

hemopoiesis

PMID:14602685[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0030097

hemopoiesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050207-1

P

Seeded From UniProt

GO:0030097

hemopoiesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050207-2

P

Seeded From UniProt

GO:0030097

hemopoiesis

PMID:16532340[9]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0030097

hemopoiesis

PMID:9499398[4]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-980202-118

P

Seeded From UniProt

GO:0030097

hemopoiesis

PMID:9499398[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0030097

hemopoiesis

PMID:9670018[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0030097

hemopoiesis

PMID:9670018[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0030099

myeloid cell differentiation

PMID:16210319[7]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0030154

cell differentiation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0221

P

Seeded From UniProt

GO:0030218

erythrocyte differentiation

PMID:14602685[8]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980526-419

P

Seeded From UniProt

GO:0030218

erythrocyte differentiation

PMID:17472439[10]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0030878

thyroid gland development

PMID:16968815[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

GO:0035050

embryonic heart tube development

PMID:17722983[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070716-6

P

Seeded From UniProt

GO:0035162

embryonic hemopoiesis

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

GO:0035162

embryonic hemopoiesis

PMID:16753140[12]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050207-1

P

Seeded From UniProt

GO:0035162

embryonic hemopoiesis

PMID:16753140[12]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

GO:0035162

embryonic hemopoiesis

PMID:18388326[13]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060405-1

P

Seeded From UniProt

GO:0035162

embryonic hemopoiesis

PMID:18718762[14]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

GO:0045603

positive regulation of endothelial cell differentiation

PMID:9499398[4]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-980202-118

P

Seeded From UniProt

GO:0045603

positive regulation of endothelial cell differentiation

PMID:9670018[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048368

lateral mesoderm development

PMID:20511544[15]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-050527-2

P

Seeded From UniProt

GO:0048823

nucleate erythrocyte development

PMID:17472439[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060405-1

P

Seeded From UniProt

GO:0048823

nucleate erythrocyte development

PMID:17472439[10]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070801-1

P

Seeded From UniProt

GO:0048844

artery morphogenesis

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048844

artery morphogenesis

PMID:17722983[11]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-070716-6

P

Seeded From UniProt

GO:0060214

endocardium formation

PMID:17722983[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060215

primitive hemopoiesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060215

primitive hemopoiesis

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060215

primitive hemopoiesis

PMID:17472439[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060215

primitive hemopoiesis

PMID:19864643[16]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0060215

primitive hemopoiesis

PMID:20410509[17]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0060216

definitive hemopoiesis

PMID:15617691[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060216

definitive hemopoiesis

PMID:15644413[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060216

definitive hemopoiesis

PMID:17472439[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060217

hemangioblast cell differentiation

PMID:14602685[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060217

hemangioblast cell differentiation

PMID:18388326[13]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060405-1

P

Seeded From UniProt

GO:0060217

hemangioblast cell differentiation

PMID:9670018[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0060217

hemangioblast cell differentiation

PMID:9670018[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060218

hemopoietic stem cell differentiation

PMID:17472439[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Dooley KA et al. (2005) Zebrafish scl functions independently in hematopoietic and endothelial development. Dev Biol 277: 522-36 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Patterson LJ et al. (2005) Scl is required for dorsal aorta as well as blood formation in zebrafish embryos. Blood 105: 3502-11 PubMed GONUTS page
  3. ↑ 3.0 3.1 Alt B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133: 3797-804 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Liao EC et al. (1998) SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev 12: 621-6 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gering M et al. (1998) The SCL gene specifies haemangioblast development from early mesoderm. EMBO J 17: 4029-45 PubMed GONUTS page
  6. ↑ Schoenebeck JJ et al. (2007) Vessel and blood specification override cardiac potential in anterior mesoderm. Dev Cell 13: 254-67 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Juarez MA et al. (2005) Distinct roles for SCL in erythroid specification and maturation in zebrafish. J Biol Chem 280: 41636-44 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Gering M et al. (2003) Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development 130: 6187-99 PubMed GONUTS page
  9. ↑ Hogan BM et al. (2006) Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish. Dev Genes Evol 216: 523-9 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Qian F et al. (2007) Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis. PLoS Biol 5: e132 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 Bussmann J et al. (2007) Early endocardial morphogenesis requires Scl/Tal1. PLoS Genet 3: e140 PubMed GONUTS page
  12. ↑ 12.0 12.1 Liu YW & Guo L (2006) Endothelium is required for the promotion of interrenal morphogenetic movement during early zebrafish development. Dev Biol 297: 44-58 PubMed GONUTS page
  13. ↑ 13.0 13.1 Xiong JW et al. (2008) An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish. Circ Res 102: 1057-64 PubMed GONUTS page
  14. ↑ Liu F et al. (2008) Fli1 acts at the top of the transcriptional network driving blood and endothelial development. Curr Biol 18: 1234-40 PubMed GONUTS page
  15. ↑ Rowlinson JM & Gering M (2010) Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos. Blood 116: 2046-56 PubMed GONUTS page
  16. ↑ Li X et al. (2009) Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. Blood 114: 5464-72 PubMed GONUTS page
  17. ↑ de Jong JL et al. (2010) Interaction of retinoic acid and scl controls primitive blood development. Blood 116: 201-9 PubMed GONUTS page
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