DANRE:RX2

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Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (taxon:7955)
Gene Name(s)	rx2
Protein Name(s)	Retinal homeobox protein Rx2
External Links
UniProt Identifier	RX2_DANRE
UniProt Accessions	O42357,
EMBL	AF001908,
RefSeq	NP_571301.1,
Ensembl	ENSDART00000059003, ENSDART00000122576,
Pfam	PF00046, PF03826,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005634	nucleus		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0043565	sequence-specific DNA binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0003700	transcription factor activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0007275	multicellular organismal development		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0006355	regulation of transcription, DNA-dependent		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0006350	transcription		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0010628	positive regulation of gene expression	PMID:19210961^[1]	IMP: Inferred from Mutant Phenotype		P	Fig 3C,D,E Morpholino mediated rx2 depletion leads to reduced pax6 expression in optic primordia	complete
	GO:0046671	negative regulation of retinal cell programmed cell death	PMID:19210961^[1]	IMP: Inferred from Mutant Phenotype		P	Fig 6E Morpholino mediated rx2 depletion leads to increased retinal cell death as shown by acridine orange assays	complete
	GO:0046549	retinal cone cell development	PMID:19210961^[1]	IMP: Inferred from Mutant Phenotype		P	Fig 9B,L Morpholino mediated rx2 depletion leads to reduced expression of cone opsins and transducins as shown by northern blots	complete
	GO:0046548	retinal rod cell development	PMID:19210961^[1]	IMP: Inferred from Mutant Phenotype		P	Fig 9C, H Morpholino mediated rx2 depletion leads to reduced expression of rod opsins and transducins as shown by northern blots	complete
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003654	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0371	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003654	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012287	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003654	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Nelson SM et al. (2009) Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish. Dev Biol 328: 24-39 PubMed GONUTS page

[PMID:19210961-0] 1.0 ^1.1 ^1.2 ^1.3 Nelson SM et al. (2009) Retinal homeobox 1 is required for retinal neurogenesis and photoreceptor differentiation in embryonic zebrafish. Dev Biol 328: 24-39 PubMed GONUTS page

[1]

DANRE:RX2

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