GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
DANRE:L1CA1
Contents |
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). ([1]) | |
| Gene Name(s) | nadl1.1 | |
| Protein Name(s) | Neural cell adhesion molecule L1.1
N-CAM-L1.1 NCAM-L1.1 | |
| External Links | ||
| EMBL | X89204 | |
| IPI | IPI00492860 | |
| PIR | T30581 | |
| UniGene | Dr.75066 | |
| ProteinModelPortal | Q90478 | |
| ZFIN | ZDB-GENE-980526-512 | |
| GeneTree | ENSGT00590000082983 | |
| HOVERGEN | HBG000144 | |
| OrthoDB | EOG4NGGKS | |
| Bgee | Q90478 | |
| GO | GO:0016021 GO:0005886 GO:0031103 GO:0007155 | |
| InterPro | IPR003961 IPR007110 IPR013783 IPR013098 IPR003599 IPR003598 | |
| Gene3D | G3DSA:2.60.40.10 | |
| Pfam | PF00041 PF07679 | |
| SMART | SM00060 SM00409 SM00408 | |
| SUPFAM | SSF49265 | |
| PROSITE | PS50853 PS50835 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0007155 |
cell adhesion |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007275 |
multicellular organismal development |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007399 |
nervous system development |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0030154 |
cell differentiation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0031103 |
axon regeneration |
IMP: Inferred from Mutant Phenotype |
ZFIN:ZDB-MRPHLNO-050628-1 |
P |
Seeded From UniProt |
|||
| GO:0060536 |
cartilage morphogenesis |
IGI: Inferred from Genetic Interaction |
|
P |
Phenotypically, nadl1.1 morphants are similar to alcama morphants: by 5 dpf they have a protruding lower jaw, cardiac edema and absent swim bladder (data not shown). Alcian blue staining reveals cartilage defects reminiscent of alcama morphants: mc and ch are changed in orientation and are fused to pq and hm, respectively (Fig. 6G–H'). Injection of nadl1.1 MO into p53−/− mutants yields similar percentages of larvae with dlx5a down-regulation and jaw abnormalities (Fig. 6F, I), indicating that the observed effect is specific to nadl1.1 knockdown. |
complete | ||
| GO:0010628 |
positive regulation of gene expression |
IMP: Inferred from Mutant Phenotype |
P |
Similar to alcama MO, nadl1.1MOaffects edn1-dependent gene expression: hand2 and dlx5a expression is strongly reduced in the arches with a more pronounced effect on the posterior arches (Fig. 6B–E). |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Becker CG et al. (2004) L1.1 is involved in spinal cord regeneration in adult zebrafish. J Neurosci 24: 7837-42 PubMed GONUTS page
- ↑ 2.0 2.1 Choudhry P et al. (2011) Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev Biol 349: 483-93 PubMed GONUTS page
ac |
imn |
p |
