Category:apolipoproteins involved in RCT

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Annotation of reverse cholesterol transport associated human apolipoproteins started in May 2009 as part of the cardiovascular GO annotation initiative, at UCL. For more information please contact r.lovering@ucl.ac.uk

Aspect ID Term HUMAN

APOA1

HUMAN

APOA2

HUMAN

APOA4

HUMAN

APOA5

HUMAN

APOC2

HUMAN

APOC3

HUMAN

APOE

HUMAN

APOM

Biological ProcessGO:0000302response to reactive oxygen species NAS
Biological ProcessGO:0001937negative regulation of endothelial cell proliferation IDA
Biological ProcessGO:0002227innate immune response in mucosa IDA
Biological ProcessGO:0002740negative regulation of cytokine secretion during immune response IDA IDA
Biological ProcessGO:0006457protein folding IDA
Biological ProcessGO:0006641triglyceride metabolic process TAS IDA  IMP IMP IDA  IMP
Biological ProcessGO:0006656phosphatidylcholine biosynthetic process IDA IDA
Biological ProcessGO:0006869lipid transport IDA IDA
Biological ProcessGO:0006898receptor-mediated endocytosis IDA
Biological ProcessGO:0006916anti-apoptosis IDA
Biological ProcessGO:0006917induction of apoptosis IDA
Biological ProcessGO:0006982response to lipid hydroperoxide IDA
Biological ProcessGO:0007010cytoskeleton organization TAS
Biological ProcessGO:0007159leukocyte adhesion IDA
Biological ProcessGO:0007186G-protein coupled receptor protein signaling pathway IDA IDA IDA
Biological ProcessGO:0007263nitric oxide mediated signal transduction IDA
Biological ProcessGO:0007271synaptic transmission, cholinergic TAS
Biological ProcessGO:0008203cholesterol metabolic process IDA  IMP IDA IDA  IMP
Biological ProcessGO:0009395phospholipid catabolic process IDA IDA
Biological ProcessGO:0009749response to glucose stimulus IDA
Biological ProcessGO:0010518positive regulation of phospholipase activity IDA
Biological ProcessGO:0010544negative regulation of platelet activation IDA
Biological ProcessGO:0010873positive regulation of cholesterol esterifi... IDA IDA IDA IDA  IMP
Biological ProcessGO:0010875positive regulation of cholesterol efflux IDA  IGI
Biological ProcessGO:0010897negative regulation of triglyceride catabol... IDA
Biological ProcessGO:0010898positive regulation of triglyceride catabolic process IDA IDA IDA
Biological ProcessGO:0010902positive regulation of very-low-density lipoprotein particle remodeling IDA IC
Biological ProcessGO:0010903negative regulation of very-low-density lipoprotein particle remodeling IDA IDA IC  IDA
Biological ProcessGO:0010916negative regulation of very-low-density lipoprotein particle clearance IDA IDA
Biological ProcessGO:0010987negative regulation of high-density lipoprotein particle clearance IMP
Biological ProcessGO:0010989negative regulation of low-density lipoprotein particle clearance IMP
Biological ProcessGO:0019430removal of superoxide radicals IDA
Biological ProcessGO:0019433triglyceride catabolic process IMP IDA
Biological ProcessGO:0019934cGMP-mediated signaling IDA
Biological ProcessGO:0030195negative regulation of blood coagulation IDA
Biological ProcessGO:0030301cholesterol transport IDA
Biological ProcessGO:0030516regulation of axon extension TAS
Biological ProcessGO:0030828positive regulation of cGMP biosynthetic process IDA
Biological ProcessGO:0031647regulation of protein stability IDA
Biological ProcessGO:0032374regulation of cholesterol transport IDA
Biological ProcessGO:0032375negative regulation of cholesterol transport IDA  IMP IMP IMP
Biological ProcessGO:0032410negative regulation of transporter activity IDA
Biological ProcessGO:0032488Cdc42 protein signal transduction IDA IDA IDA
Biological ProcessGO:0032805positive regulation of low-density lipoprot... IDA
Biological ProcessGO:0033344cholesterol efflux IDA IDA IDA IDA IDA IDA IDA  IMP
Biological ProcessGO:0033700phospholipid efflux IDA IDA IDA IDA IDA IDA
Biological ProcessGO:0034370triglyceride-rich lipoprotein particle remo... IDA TAS
Biological ProcessGO:0034371chylomicron remodeling IC IC
Biological ProcessGO:0034372very-low-density lipoprotein particle remodeling IDA TAS IDA  IGI
Biological ProcessGO:0034374low-density lipoprotein particle remodeling IDA
Biological ProcessGO:0034375high-density lipoprotein particle remodeling IC IDA IC IMP IGI IMP
Biological ProcessGO:0034378chylomicron assembly TAS
Biological ProcessGO:0034379very-low-density lipoprotein particle assembly IDA  TAS
Biological ProcessGO:0034380high-density lipoprotein particle assembly IDA IDA IDA ISS
Biological ProcessGO:0034381lipoprotein particle clearance TAS
Biological ProcessGO:0034382chylomicron remnant clearance IDA IDA IMP
Biological ProcessGO:0034383low-density lipoprotein particle clearance IMP
Biological ProcessGO:0034384high-density lipoprotein particle clearance IC  IDA IDA IMP IMP IDA ISS
Biological ProcessGO:0034445negative regulation of plasma lipoprotein o... IDA
Biological ProcessGO:0034447very-low-density lipoprotein particle clear... IDA  IMP
Biological ProcessGO:0042246tissue regeneration IEP
Biological ProcessGO:0042632cholesterol homeostasis IMP IDA IDA IC IMP IDA IC
Biological ProcessGO:0042744hydrogen peroxide catabolic process IDA
Biological ProcessGO:0043407negative regulation of MAP kinase activity IDA
Biological ProcessGO:0043537negative regulation of blood vessel endothelial cell migration IDA
Biological ProcessGO:0043691reverse cholesterol transport IMP IDA IDA IC IC IDA ISS
Biological ProcessGO:0044240multicellular organismal lipid catabolic pr... IDA
Biological ProcessGO:0045416positive regulation of interleukin-8 biosynthetic process IDA
Biological ProcessGO:0045541negative regulation of cholesterol biosynthetic process IDA
Biological ProcessGO:0045717negative regulation of fatty acid biosynthe... IDA
Biological ProcessGO:0045723positive regulation of fatty acid biosynthetic process IDA IDA IDA
Biological ProcessGO:0045833negative regulation of lipid metabolic process IDA IDA
Biological ProcessGO:0046340diacylglycerol catabolic process IDA
Biological ProcessGO:0046470phosphatidylcholine metabolic process IDA
Biological ProcessGO:0046907intracellular transport TAS
Biological ProcessGO:0048168regulation of neuronal synaptic plasticity TAS
Biological ProcessGO:0048260positive regulation of receptor-mediated en... TAS
Biological ProcessGO:0048261negative regulation of receptor-mediated en... IDA IDA
Biological ProcessGO:0050713negative regulation of interleukin-1 beta secretion IDA
Biological ProcessGO:0050728negative regulation of inflammatory response IC
Biological ProcessGO:0050821protein stabilization IDA
Biological ProcessGO:0050995negative regulation of lipid catabolic process IDA IDA
Biological ProcessGO:0050996positive regulation of lipid catabolic process IDA IDA
Biological ProcessGO:0051000positive regulation of nitric-oxide synthase activity IDA
Biological ProcessGO:0051005negative regulation of lipoprotein lipase a... IDA
Biological ProcessGO:0051006positive regulation of lipoprotein lipase activity IDA IDA IDA
Biological ProcessGO:0051044positive regulation of membrane protein ectodomain proteolysis IDA
Biological ProcessGO:0051345positive regulation of hydrolase activity IDA
Biological ProcessGO:0055088lipid homeostasis IDA
Biological ProcessGO:0055090acylglycerol homeostasis IDA  IMP
Biological ProcessGO:0060192negative regulation of lipase activity IDA
Biological ProcessGO:0060588negative regulation of lipoprotein lipid oxidation IDA
Biological ProcessGO:0060621negative regulation of cholesterol import IDA IMP
Biological ProcessGO:0060695negative regulation of cholesterol transporter activity IDA
Biological ProcessGO:0060697positive regulation of phospholipid catabolic process IDA
Biological ProcessGO:0065005protein-lipid complex assembly IMP
Biological ProcessGO:0070328triglyceride homeostasis IMP IMP IMP
Biological ProcessGO:0070508cholesterol import IMP
Cellular ComponentGO:0005576extracellular region EXP EXP  NAS EXP  NAS IDA EXP  NAS EXP EXP
Cellular ComponentGO:0005615extracellular space IDA IDA IDA IDA
Cellular ComponentGO:0005634nucleus IDA
Cellular ComponentGO:0005737cytoplasm IDA NAS  TAS
Cellular ComponentGO:0005788endoplasmic reticulum lumen EXP EXP EXP
Cellular ComponentGO:0005886plasma membrane EXP EXP
Cellular ComponentGO:0005887integral to plasma membrane TAS
Cellular ComponentGO:0030141secretory granule EXP
Cellular ComponentGO:0030425dendrite NAS
Cellular ComponentGO:0031410cytoplasmic vesicle IDA
Cellular ComponentGO:0034361very-low-density lipoprotein particle IDA IDA IDA IDA IDA IDA IDA IDA
Cellular ComponentGO:0034362low-density lipoprotein particleNOT IDA IDA IDA IDA
Cellular ComponentGO:0034363intermediate-density lipoprotein particle IDA IDA IDA
Cellular ComponentGO:0034364high-density lipoprotein particle IDA IDA IDA IDA IDA
Cellular ComponentGO:0034365discoidal high-density lipoprotein particle IDA
Cellular ComponentGO:0034366spherical high-density lipoprotein particle IDA IDA IDA IDA IDA
Cellular ComponentGO:0042627chylomicron IDA IDA IDA IDA IDA IDA
Cellular ComponentGO:0043025cell soma NAS
Cellular ComponentGO:0043231intracellular membrane-bounded organelle IDA
Molecular FunctionGO:0001540beta-amyloid binding IDA IDA
Molecular FunctionGO:0005319lipid transporter activity NAS IDA TAS IDA IDA  TAS
Molecular FunctionGO:0005507copper ion binding IDA
Molecular FunctionGO:0005515protein binding IPI IPI IPI
Molecular FunctionGO:0005543phospholipid binding IDA IDA IDA IDA IDA
Molecular FunctionGO:0008047enzyme activator activity IDA
Molecular FunctionGO:0008201heparin binding IDA contributes_to IDA IDA
Molecular FunctionGO:0008289lipid binding IDA IMP IDA IDA IDA
Molecular FunctionGO:0015485cholesterol binding IDA IDA IC
Molecular FunctionGO:0016004phospholipase activator activity IDA
Molecular FunctionGO:0016209antioxidant activity IDA IDA
Molecular FunctionGO:0017127cholesterol transporter activity IMP contributes_to IDAcontributes_to IDA IDA
Molecular FunctionGO:0019899enzyme binding IPI IDA
Molecular FunctionGO:0030234enzyme regulator activity IDA
Molecular FunctionGO:0031210phosphatidylcholine binding IDA IDA IDA
Molecular FunctionGO:0034190apolipoprotein receptor binding IPI IPI
Molecular FunctionGO:0034191apolipoprotein A-I receptor binding IPI
Molecular FunctionGO:0042802identical protein binding IPI IDA
Molecular FunctionGO:0042803protein homodimerization activity IDA IDA IMP IDA
Molecular FunctionGO:0043274phospholipase binding IPI
Molecular FunctionGO:0043499eukaryotic cell surface bindingcontributes_to IDA
Molecular FunctionGO:0046911metal chelating activity IDA
Molecular FunctionGO:0046982protein heterodimerization activity IPI IMP IPI
Molecular FunctionGO:0048156tau protein binding IPI
Molecular FunctionGO:0050750low-density lipoprotein receptor binding IPI IDA  IPI
Molecular FunctionGO:0055102lipase inhibitor activity IDA IDA IDA
Molecular FunctionGO:0060228phosphatidylcholine-sterol O-acyltransferas... IDA IDA IDA IDA
Molecular FunctionGO:0060229lipase activator activity IMP
Molecular FunctionGO:0060230lipoprotein lipase activator activity IDA IDA
Molecular FunctionGO:0070325lipoprotein receptor binding IPI IPI IPI IPI
Molecular FunctionGO:0070326very-low-density lipoprotein receptor binding IDA  IPI
Molecular FunctionGO:0070653high-density lipoprotein receptor binding IPI IPI IPI
Cellular ComponentGO:0030139endocytic vesicle IDA

Cellular Component graph



RefGenome graph at MGI.

Molecular Function graph



RefGenome graph at MGI.

Biological Process graph



RefGenome graph at MGI.


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