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Category:GO:1990000 ! amyloid fibril formation
name: amyloid fibril formation
namespace: biological_process
def: "The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins." [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159]
comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
synonym: "amyloid fibril assembly" RELATED []
synonym: "amyloid structure assembly" RELATED []
synonym: "amyloid structure formation" RELATED []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0097435 ! supramolecular fiber organization
AmiGO
<GOterm>GO:1990000</GOterm>
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This category has the following 2 subcategories, out of 2 total.
