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Category:GO:0097452 ! GAIT complex
name: GAIT complex
namespace: cellular_component
def: "A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP." [GOC:br, PMID:15479637, PMID:23071094]
synonym: "gamma interferon-activated inhibitor of translation complex" EXACT []
synonym: "IFN-gamma-activated inhibitor of translation complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
AmiGO
<GOterm>GO:0097452</GOterm>
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