GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

Category:GO:0097342 ! ripoptosome

From GONUTS
Jump to: navigation, search

DAG for GO:0097342id: GO:0097342

name: ripoptosome
namespace: cellular_component
def: "A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:bhm, GOC:mtg_apoptosis, PMID:22265414, PMID:22274400]
comment: It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
synonym: "necrosome" RELATED []
synonym: "TNFR1 complex II" NARROW [PMID:22089168]
synonym: "Tnfr1-CII" NARROW [PMID:22089168]
is_a: GO:1902494 ! catalytic complex
relationship: part_of: GO:0005829 ! cytosol

AmiGO <GOterm>GO:0097342</GOterm>
Gene Ontology Home


The contents of this box are automatically generated. You can help by adding information to the "Notes"

Usage Notes

References

See Help:References for how to manage references in GONUTS.

Pages in category "GO:0097342 ! ripoptosome"

The following 5 pages are in this category, out of 5 total.


Jump to pages starting with: H M P