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Category:GO:0072559 ! NLRP3 inflammasome complex
name: NLRP3 inflammasome complex
namespace: cellular_component
def: "A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]
synonym: "NALP3 inflammasome complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
AmiGO
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