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Category:GO:0070578 ! RISC-loading complex
name: RISC-loading complex
namespace: cellular_component
def: "A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP." [GOC:ab, PMID:18178619]
synonym: "microRNA loading complex" EXACT [GOC:ab]
synonym: "miRLC" EXACT [GOC:ab]
synonym: "RLC" RELATED [GOC:ab, GOC:mah]
is_a: GO:0030529 ! ribonucleoprotein complex
AmiGO
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