Category:GO:0070266 ! necroptotic process

name: necroptotic process
namespace: biological_process
alt_id: GO:0060553
alt_id: GO:0060554
alt_id: GO:0060555
def: "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former." [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153]
comment: Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
synonym: "activation of necroptosis" RELATED []
synonym: "activation of necroptosis by extracellular signals" RELATED []
synonym: "activation of necroptosis in response to extracellular signals" RELATED []
synonym: "activation of necroptosis of activated-T cells" RELATED []
synonym: "establishment of necroptosis" RELATED []
synonym: "establishment of necroptosis of activated-T cells" RELATED []
synonym: "extracellular signal-induced necroptosis" RELATED []
synonym: "induction of necroptosis" BROAD []
synonym: "induction of necroptosis by extracellular signals" BROAD []
synonym: "induction of necroptosis of activated-T cells" BROAD []
synonym: "necroptosis" NARROW []
synonym: "PARP-dependent cell death" RELATED []
synonym: "parthanatos" RELATED []
synonym: "programmed necrosis" BROAD [Reactome:R-HSA-5213460.1]
synonym: "programmed necrotic cell death" BROAD [GOC:mah]
synonym: "RIPK1-mediated regulated necrosis" EXACT [Reactome:R-HSA-5213460.1]
synonym: "TNF-induced necroptosis" NARROW [PMID:21876153]
is_a: GO:0097300 ! programmed necrotic cell death

AmiGO <GOterm>GO:0070266</GOterm>
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