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Category:GO:0070054 ! mRNA splicing, via endonucleolytic cleavage and ligation
name: mRNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
alt_id:GO:0061012
def: "Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, GOC:mah]
comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
subset: gosubset_prok
synonym: "cytosolic mRNA splicing" RELATED [GOC:curators]
is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation
is_a: GO:0006397 ! mRNA processing
AmiGO
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