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Category:GO:0051870 ! methotrexate binding
name: methotrexate binding
namespace: molecular_function
def: "Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0033218 ! amide binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
AmiGO
<GOterm>GO:0051870</GOterm>
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