Category:GO:0051213 ! dioxygenase activity

id: GO:0051213

name: dioxygenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

AmiGO

Last version checked date: 06:02:2012 15:08 saved-by: rfoulger auto-generated-by: OBO-Edit 2.1

Last updated date: 19:11:2010 16:43

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Usage Notes

Oxygenases are enzymes that incorporate oxygen atoms from O₂ into the product(s). Monooxygenases catalyze the incorporation of one oxygen atom from O₂ into the product; the other oxygen atom is reduced to H₂O.^[1] Dioxygenases incorporate both atoms of oxygen from a molecule of O₂ into the product (or products) of the reaction^[1]. Note that one of the molecules incorporating an oxygen may not be obvious from simplified descriptions of the reaction mechanism. For example, there are many ketoglutarate-dependent dioxygenases that convert ketoglutarate to succinate while transferring an oxygen to a more specialized substrate. In reading papers about such enzymes, the formation of succinate can be missed easily.

References

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1. ↑ ^{1.0 1.1} Bugg T.D.H. (2003) Dioxygenase enzymes: catalytic mechanisms and chemical models. Tetrahedron 59(36):7075-7101