Category:GO:0046776 ! symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I

name: symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
alt_id: GO:0039591
def: "A process by which a symbiont inhibits or disrupts the normal processing and presentation of a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, some viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response." [GOC:add, GOC:bf, PMID:10227971, PMID:10859382, PMID:9175839]
synonym: "inhibition of host MHC class I molecule presentation by virus" NARROW []
synonym: "negative regulation by virus of MHC class I cell surface presentation" NARROW []
synonym: "suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "suppression by virus of host MHC class I cell surface presentation" NARROW [GOC:add]
synonym: "suppression by virus of host tapasin activity" NARROW []
synonym: "suppression by virus of MHC class I cell surface presentation in host" NARROW []
is_a: GO:0039588 ! symbiont-mediated suppression of host antigen processing and presentation

AmiGO <GOterm>GO:0046776</GOterm>
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