Category:GO:0045857 ! negative regulation of molecular function, epigenetic

name: negative regulation of molecular function, epigenetic
namespace: biological_process
def: "Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of protein activity, epigenetic" EXACT []
synonym: "down-regulation of protein activity, epigenetic" EXACT []
synonym: "downregulation of protein activity, epigenetic" EXACT []
synonym: "inhibition of protein activity, epigenetic" NARROW []
synonym: "negative regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040030 ! regulation of molecular function, epigenetic
is_a: GO:0044092 ! negative regulation of molecular function

AmiGO

Pages in category "GO:0045857 ! negative regulation of molecular function, epigenetic"

The following 3 pages are in this category, out of 3 total.

A

• ARATH:LHP1

T

• TAIR:CLF
• TAIR:TFL2