Category:GO:0045252 ! oxoglutarate dehydrogenase complex

name: oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:10672230]
comment: The catalytic activities of the individual components of this complex are represented by the molecular function terms 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'oxoglutarate dehydrogenase (NAD+) activity ; GO:0034602'.
subset: goslim_pir
synonym: "alpha-ketoglutarate dehydrogenase complex" EXACT []
synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT []
synonym: "KGDHC" EXACT []
xref: Wikipedia:Oxoglutarate_dehydrogenase_complex
is_a: GO:0045239 ! tricarboxylic acid cycle heteromeric enzyme complex
is_a: GO:0045240 ! alpha-ketoacid dehydrogenase complex

AmiGO <GOterm>GO:0045252</GOterm>
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