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Category:GO:0045190 ! isotype switching
name: isotype switching
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149]
comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
synonym: "class switch recombination" EXACT []
synonym: "class switching" EXACT []
synonym: "isotype switch recombination" EXACT []
xref: Wikipedia:Immunoglobulin_class_switching
is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response
is_a: GO:0002312 ! B cell activation involved in immune response
AmiGO
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This term has the following 7 child terms, out of 7 total.
