Category:GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus

name: cytoplasmic pattern recognition receptor signaling pathway in response to virus
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:17328678, PMID:18272355, PMID:19531363]
comment: This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has detected the viral RNA. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2.
synonym: "cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway" NARROW [PMID:17328678]
synonym: "cytoplasmic pattern recognition receptor signalling pathway in response to virus" EXACT [GOC:mah]
synonym: "RIG-I-like receptor (RLR) signaling pathway" NARROW [PMID:21626883]
synonym: "RIG-I/MDA5 signaling pathway" NARROW [PMID:21187438]
synonym: "RIG-like helicase signaling pathway" NARROW [PMID:18272355]
synonym: "RIG-like receptor signaling pathway" NARROW [PMID:19531363]
synonym: "RLH signaling pathway" NARROW [PMID:18272355]
synonym: "RLR signaling pathway" NARROW [PMID:19531363]
synonym: "virus-induced cytoplasmic pattern recognition receptor signaling pathway" EXACT [GOC:bf]
is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway
relationship:part_of: GO:0051607 ! defense response to virus

AmiGO

Child Terms

This term has the following 4 child terms, out of 4 total.

• [+] GO:0039529 ! RIG-I signaling pathway (3)
• [+] GO:0039530 ! MDA-5 signaling pathway (3)
• [+] GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (3)
• [+] GO:0039532 ! negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (3)