Category:GO:0036498 ! IRE1-mediated unfolded protein response

name: IRE1-mediated unfolded protein response
namespace: biological_process
def: "The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB." [GOC:bf, GOC:PARL, PMID:22013210]
comment: Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
synonym: "endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:bf]
synonym: "ERN1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "inositol-requiring enzyme 1-mediated unfolded protein response" RELATED [HGNC:3449]
synonym: "inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [PMID:22013210]
synonym: "IRE1 branch of UPR" EXACT [GOC:bf]
synonym: "IRE1 signal transduction pathway" BROAD [GOC:bf]
synonym: "IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf]
synonym: "IRE1alpha unfolded protein response" NARROW [PMID:22013210]
synonym: "IRE1p unfolded protein response" NARROW [PMID:22013210]
synonym: "UPR signaling by IRE1 stress sensor" EXACT [GOC:bf]
is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response

AmiGO <GOterm>GO:0036498</GOterm>
Gene Ontology Home