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Category:GO:0035333 ! Notch receptor processing, ligand-dependent
name: Notch receptor processing, ligand-dependent
namespace: biological_process
def: "The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD)." [GOC:bf, PMID:12651094]
synonym: "Notch S2 cleavage" NARROW [PMID:12651094]
synonym: "Notch S3 cleavage" NARROW [PMID:12651094]
is_a: GO:0031293 ! membrane protein intracellular domain proteolysis
relationship:part_of: GO:0007219 ! Notch signaling pathway
relationship:part_of: GO:0007220 ! Notch receptor processing
AmiGO
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