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Category:GO:0035329 ! hippo signaling pathway
name: hippo signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423]
synonym: "Salvador-Warts-Hippo signaling pathway" NARROW []
synonym: "SWH pathway" NARROW []
is_a: GO:0023034 ! intracellular signaling pathway
is_a: GO:0035556 ! intracellular signal transduction
AmiGO
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This term has the following 3 child terms, out of 3 total.
