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Category:GO:0035279 ! gene silencing by miRNA, mRNA cleavage
name: gene silencing by miRNA, mRNA cleavage
namespace: biological_process
def: "The process by which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically direct cleavage by base pairing with near-perfect complementarity to the target mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554]
synonym: "miRNA-mediated gene silencing, mRNA cleavage" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006379 ! mRNA cleavage
relationship:part_of: GO:0035195 ! gene silencing by miRNA
AmiGO
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