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Category:GO:0034747 ! Axin-APC-beta-catenin-GSK3B complex
name: Axin-APC-beta-catenin-GSK3B complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), Axin-1, beta-catenin, and glycogen synthase kinase 3 beta. Formation of this complex leads to phosphorylation of beta-catenin and down-regulation of beta-catenin activity." [PMID:9601641]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
AmiGO
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