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Category:GO:0034450 ! ubiquitin-ubiquitin ligase activity
name: ubiquitin-ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine. This reaction is the ligation of ubiquitin groups, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]
synonym: "E4" EXACT []
xref: Reactome:REACT_24943 "Pellino ubiquitinates hp-IRAK1, Homo sapiens"
xref: Reactome:REACT_24976 "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
, Homo sapiens"
xref: Reactome:REACT_27265 "Activated TRAF6 synthesizes free K63 linked pUb chains., Gallus gallus"
xref: Reactome:REACT_75823 "TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex, Gallus gallus"
xref: Reactome:REACT_75827 "ITCH homolog downregulates MDA5/IPS1 signaling, Gallus gallus"
xref: Reactome:REACT_75854 "TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex, Gallus gallus"
is_a: GO:0004842 ! ubiquitin-protein ligase activity
AmiGO
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