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Category:GO:0034205 ! amyloid-beta formation
name: amyloid-beta formation
namespace: biological_process
def: "The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP)." [GOC:mah]
comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000).
synonym: "beta-amyloid formation" EXACT []
synonym: "beta-amyloid polypeptide formation from amyloid precursor protein" EXACT []
synonym: "beta-amyloid polypeptide formation from APP" EXACT []
is_a: GO:0042987 ! amyloid precursor protein catabolic process
is_a: GO:0050435 ! amyloid-beta metabolic process
AmiGO
<GOterm>GO:0034205</GOterm>
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This category has the following 2 subcategories, out of 2 total.
