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Category:GO:0033781 ! cholesterol 24-hydroxylase activity
name: cholesterol 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+)." [EC:1.14.13.98, RHEA:22719]
synonym: "cholesterol 24-monooxygenase activity" EXACT [EC:1.14.13.98]
synonym: "cholesterol 24S-hydroxylase activity" EXACT [EC:1.14.13.98]
synonym: "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity" EXACT [EC:1.14.13.98]
synonym: "CYP46" RELATED [EC:1.14.13.98]
synonym: "CYP46A1" RELATED [EC:1.14.13.98]
synonym: "cytochrome P450 46A1" RELATED [EC:1.14.13.98]
xref: EC:1.14.13.98
xref: KEGG:R07207
xref: MetaCyc:1.14.13.98-RXN
xref: Reactome:REACT_100868 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Xenopus tropicalis"
xref: Reactome:REACT_10129 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Homo sapiens"
xref: Reactome:REACT_102867 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Sus scrofa"
xref: Reactome:REACT_78490 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Mus musculus"
xref: Reactome:REACT_79067 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Taeniopygia guttata"
xref: Reactome:REACT_79090 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Gallus gallus"
xref: Reactome:REACT_79585 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Canis familiaris"
xref: Reactome:REACT_83550 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Rattus norvegicus"
xref: Reactome:REACT_94780 "Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1, Bos taurus"
xref: RHEA:22719
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
AmiGO
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