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Category:GO:0033778 ! 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
name: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+)." [EC:1.14.13.95, RHEA:10507]
synonym: "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity" EXACT [EC:1.14.13.95]
synonym: "7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.95]
synonym: "CYP12" RELATED [EC:1.14.13.95]
synonym: "HCO 12alpha-hydroxylase activity" EXACT [EC:1.14.13.95]
synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.95]
xref: EC:1.14.13.95
xref: KEGG:R04826
xref: MetaCyc:1.14.13.95-RXN
xref: Reactome:REACT_10016 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Homo sapiens"
xref: Reactome:REACT_10028 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Homo sapiens"
xref: Reactome:REACT_10071 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Homo sapiens"
xref: Reactome:REACT_101155 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Canis familiaris"
xref: Reactome:REACT_102486 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Rattus norvegicus"
xref: Reactome:REACT_103388 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Xenopus tropicalis"
xref: Reactome:REACT_106615 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Rattus norvegicus"
xref: Reactome:REACT_107159 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Bos taurus"
xref: Reactome:REACT_110150 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Bos taurus"
xref: Reactome:REACT_112283 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_113628 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_114278 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_114416 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Oryza sativa"
xref: Reactome:REACT_114504 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_114554 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Oryza sativa"
xref: Reactome:REACT_114957 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_115001 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_115030 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_115216 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_115313 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Oryza sativa"
xref: Reactome:REACT_30306 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Canis familiaris"
xref: Reactome:REACT_34765 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Mus musculus"
xref: Reactome:REACT_79540 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Taeniopygia guttata"
xref: Reactome:REACT_79551 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Rattus norvegicus"
xref: Reactome:REACT_79575 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Canis familiaris"
xref: Reactome:REACT_80434 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Danio rerio"
xref: Reactome:REACT_84548 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Danio rerio"
xref: Reactome:REACT_88158 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_90466 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Mus musculus"
xref: Reactome:REACT_92496 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_92610 "4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one, Danio rerio"
xref: Reactome:REACT_93852 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_94412 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Mus musculus"
xref: Reactome:REACT_99087 "4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_99746 "4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one, Bos taurus"
xref: RHEA:10507
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
AmiGO
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Pages in category "GO:0033778 ! 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity"
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