Category:GO:0032640 ! tumor necrosis factor production

name: tumor necrosis factor production
namespace: biological_process
alt_id: GO:0042533
alt_id: GO:1990774
def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:mah, PMID:10891884, PMID:15560120]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "cachectin production" EXACT []
synonym: "TNF alpha biosynthesis" NARROW []
synonym: "TNF biosynthesis" NARROW []
synonym: "TNF biosynthetic process" NARROW []
synonym: "TNF production" EXACT []
synonym: "TNF-alpha biosynthesis" NARROW []
synonym: "TNF-alpha biosynthetic process" NARROW []
synonym: "TNF-alpha production" RELATED []
synonym: "Tnfa production" RELATED []
synonym: "tumor necrosis factor anabolism" NARROW []
synonym: "tumor necrosis factor biosynthesis" NARROW []
synonym: "tumor necrosis factor biosynthetic process" NARROW []
synonym: "tumor necrosis factor formation" NARROW []
synonym: "tumor necrosis factor secretion" NARROW []
synonym: "tumor necrosis factor synthesis" NARROW []
synonym: "tumor necrosis factor-alpha production" RELATED []
is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production

AmiGO <GOterm>GO:0032640</GOterm>
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