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Category:GO:0031422 ! RecQ helicase-Topo III complex
name: RecQ helicase-Topo III complex
namespace: cellular_component
def: "A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human." [PMID:15889139]
synonym: "Sgs1-Top3 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
AmiGO
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Usage Notes
Helicases generally separate duplex nucleic acids into separate strands. RecQ helicase couples the energy of ATP hydrolysis in order to unwind double-stranded DNA and RNA molecules. RecQ is involved with recombinational repair within the RecF pathway. Specifically, recQ is used for double stranded DNA break (DSB) repair by generating the single stranded DNA. This ssDNA is then processed by other enzymes in the RecF pathway, which manipulate the ssDNA so it will be competent for recombination. [1]
Associated syndromes with mutations on the recQ gene include Werner's, Bloom's, and Rothmund-Thomson Syndrome, which are all autosomal recessive disorders. Werner's Syndrome occurs due to a mutation on the WRN gene and causes loss of skin elasticity, osteoporosis, and atherosclerosis in humans. Bloom's occurs on the BLM gene and is associated with immuno-deficiency, male infertility, and predisposition to all types of cancer. Rothmund-Thomson syndrome is due to a mutation on the RECQ4 gene and causes growth deficiency, early graying and hair loss, and increased cancer incidence in humans. [2]
See also
RecQ helicase mechanisms. [1]
The roles of RecQ helicase in the human genome and associated syndromes. [3]
Mutations in RecQ helicase and associated syndromes. [4]
Molecular Genetics of RecQ helicase disorders [5]
References
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- ↑ 1.0 1.1 Killoran MP & Keck JL (2006) Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res 34: 4098-105 PubMed GONUTS page
- ↑ Mohaghegh P & Hickson ID (2001) DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum Mol Genet 10: 741-6 PubMed GONUTS page
- ↑ Bohr VA (2008) Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance. Trends Biochem Sci 33: 609-20 PubMed GONUTS page
- ↑ Furuichi Y (2001) Premature aging and predisposition to cancers caused by mutations in RecQ family helicases. Ann N Y Acad Sci 928: 121-31 PubMed GONUTS page
- ↑ Hanada K & Hickson ID (2007) Molecular genetics of RecQ helicase disorders. Cell Mol Life Sci 64: 2306-22 PubMed GONUTS page
External links
Pages in category "GO:0031422 ! RecQ helicase-Topo III complex"
The following 3 pages are in this category, out of 3 total.
