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Category:GO:0031202 ! RNA splicing factor activity, transesterification mechanism
name: RNA splicing factor activity, transesterification mechanism
namespace: molecular_function
alt_id:GO:0000385
def: "An activity which assists splicing of substrate RNA(s) by facilitating the formation and stabilization of a series of catalytic conformations in which key RNA sequences are positioned for a series of two transesterification reactions which result in removal of the intron sequence and joining of two exons." [GOC:krc]
comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism.
synonym: "pre-mRNA splicing factor activity" RELATED []
synonym: "spliceosomal catalysis" EXACT []
xref: Reactome:160901 "RNA splicing factor activity, transesterification mechanism"
is_a: GO:0003824 ! catalytic activity
AmiGO
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