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Category:GO:0030877 ! beta-catenin destruction complex
name: beta-catenin destruction complex
namespace: cellular_component
alt_id: GO:0034742
alt_id: GO:0034747
def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "23S APC complex" NARROW []
synonym: "APC-Axin-1-beta-catenin complex" EXACT []
synonym: "Axin-APC-beta-catenin-GSK3B complex" EXACT []
synonym: "BDC" EXACT [GOC:bf, GOC:PARL, PMID:22899650]
synonym: "beta-catenin degradation complex" EXACT []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex
AmiGO
<GOterm>GO:0030877</GOterm>
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