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Category:GO:0017113 ! dihydropyrimidine dehydrogenase (NADP+) activity
name: dihydropyrimidine dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2]
subset: gosubset_prok
synonym: "4,5-dihydrothymine: oxidoreductase activity" EXACT [EC:1.3.1.2]
synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.2]
synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.2]
synonym: "DHPDH" RELATED [EC:1.3.1.2]
synonym: "DHU dehydrogenase activity" EXACT [EC:1.3.1.2]
synonym: "dihydropyrimidine dehydrogenase activity" EXACT []
synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2]
synonym: "dihydrouracil dehydrogenase (NADP)" EXACT [EC:1.3.1.2]
synonym: "dihydrouracil dehydrogenase (NADP+) activity" EXACT [EC:1.3.1.2]
synonym: "DPD" RELATED [EC:1.3.1.2]
synonym: "hydropyrimidine dehydrogenase activity" EXACT [EC:1.3.1.2]
xref: EC:1.3.1.2
xref: MetaCyc:1.3.1.2-RXN
xref: Reactome:REACT_100185 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Bos taurus"
xref: Reactome:REACT_101500 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Drosophila melanogaster"
xref: Reactome:REACT_102325 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Escherichia coli"
xref: Reactome:REACT_102503 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Caenorhabditis elegans"
xref: Reactome:REACT_102856 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Oryza sativa"
xref: Reactome:REACT_104406 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_104716 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_104929 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Canis familiaris"
xref: Reactome:REACT_1067 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Homo sapiens"
xref: Reactome:REACT_106968 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Rattus norvegicus"
xref: Reactome:REACT_107377 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Gallus gallus"
xref: Reactome:REACT_107631 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Mus musculus"
xref: Reactome:REACT_28626 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Danio rerio"
xref: Reactome:REACT_29373 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Bos taurus"
xref: Reactome:REACT_31473 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Danio rerio"
xref: Reactome:REACT_33387 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Escherichia coli"
xref: Reactome:REACT_546 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Homo sapiens"
xref: Reactome:REACT_78060 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Xenopus tropicalis"
xref: Reactome:REACT_80344 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Dictyostelium discoideum"
xref: Reactome:REACT_80891 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Caenorhabditis elegans"
xref: Reactome:REACT_81619 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Sus scrofa"
xref: Reactome:REACT_85525 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Arabidopsis thaliana"
xref: Reactome:REACT_85843 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Rattus norvegicus"
xref: Reactome:REACT_86765 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Gallus gallus"
xref: Reactome:REACT_87828 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Taeniopygia guttata"
xref: Reactome:REACT_88182 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Mus musculus"
xref: Reactome:REACT_89315 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Canis familiaris"
xref: Reactome:REACT_89636 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Oryza sativa"
xref: Reactome:REACT_92348 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Arabidopsis thaliana"
xref: Reactome:REACT_92956 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Sus scrofa"
xref: Reactome:REACT_95786 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+, Taeniopygia guttata"
xref: Reactome:REACT_98344 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+, Drosophila melanogaster"
xref: RHEA:18096
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
AmiGO
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