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Category:GO:0016975 ! alpha-2 macroglobulin
This GO term has been obsoleted.
Do not annotate to it.
id: GO:0016975
name: alpha-2 macroglobulin
namespace: molecular_function
def: "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004866 ! endopeptidase inhibitor activity
AmiGO
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