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Category:GO:0008705 ! methionine synthase activity
name: methionine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." [EC:2.1.1.13, RHEA:11175]
subset: gosubset_prok
synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" EXACT [EC:2.1.1.13]
synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT []
synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "cobalamin-dependent methionine synthase activity" EXACT [EC:2.1.1.13]
synonym: "MetH" RELATED [EC:2.1.1.13]
synonym: "methionine synthase (cobalamin-dependent) activity" EXACT [EC:2.1.1.13]
synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13]
synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13]
synonym: "tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "tetrahydropteroylglutamate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "tetrahydropteroylglutamic methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13]
xref: EC:2.1.1.13
xref: KEGG:R00946
xref: MetaCyc:HOMOCYSMETB12-RXN
xref: Reactome:REACT_108964 "Methionine is reformed, Staphylococcus aureus N315"
xref: Reactome:REACT_109401 "Methionine is reformed, Xenopus tropicalis"
xref: Reactome:REACT_32037 "Methionine is reformed, Canis familiaris"
xref: Reactome:REACT_33315 "Methionine is reformed, Rattus norvegicus"
xref: Reactome:REACT_6739 "Methionine is reformed, Homo sapiens"
xref: Reactome:REACT_79867 "Methionine is reformed, Escherichia coli"
xref: Reactome:REACT_82450 "Methionine is reformed, Taeniopygia guttata"
xref: Reactome:REACT_87311 "Methionine is reformed, Mus musculus"
xref: Reactome:REACT_88342 "Methionine is reformed, Mycobacterium tuberculosis"
xref: Reactome:REACT_89478 "Methionine is reformed, Gallus gallus"
xref: Reactome:REACT_91637 "Methionine is reformed, Bos taurus"
xref: Reactome:REACT_92492 "Methionine is reformed, Sus scrofa"
xref: Reactome:REACT_93034 "Methionine is reformed, Caenorhabditis elegans"
xref: Reactome:REACT_97474 "Methionine is reformed, Danio rerio"
xref: Reactome:REACT_98785 "Methionine is reformed, Dictyostelium discoideum"
xref: RHEA:11175
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity
AmiGO
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References
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A review of methionine synthases [1].
A comparative description of cobalamin-dependent and cobalamin-independent methionine synthases [2].
- ↑ Banerjee RV & Matthews RG (1990) Cobalamin-dependent methionine synthase. FASEB J 4: 1450-9 PubMed GONUTS page
- ↑ González JC et al. (1992) Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem. Biochemistry 31: 6045-56 PubMed GONUTS page
