Category:GO:0008547 ! protein-synthesizing GTPase activity

This GO term has been obsoleted. Do not annotate to it.

id: GO:0008547
name: protein-synthesizing GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924 ! GTPase activity
replaced_by: GO:0006412 ! translation
consider: GO:0008135 ! translation factor activity, nucleic acid binding

AmiGO