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Category:GO:0008398 ! sterol 14-demethylase activity
name: sterol 14-demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [EC:1.14.13.70]
subset: gosubset_prok
synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.13.70]
synonym: "cytochrome P450 CYP51" NARROW []
synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70]
synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70]
synonym: "lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70]
synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70]
synonym: "sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70]
synonym: "sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70]
synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70]
xref: EC:1.14.13.70
xref: MetaCyc:1.14.13.70-RXN
xref: Reactome:REACT_10006 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_29216 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_32427 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Danio rerio"
xref: Reactome:REACT_32453 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_78438 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Xenopus tropicalis"
xref: Reactome:REACT_79266 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Saccharomyces cerevisiae"
xref: Reactome:REACT_80783 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Oryza sativa"
xref: Reactome:REACT_87749 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Mycobacterium tuberculosis"
xref: Reactome:REACT_92607 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Mus musculus"
xref: Reactome:REACT_93847 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Schizosaccharomyces pombe"
xref: Reactome:REACT_93854 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Gallus gallus"
xref: Reactome:REACT_95701 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Bos taurus"
xref: Reactome:REACT_96210 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_98680 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Dictyostelium discoideum"
xref: Reactome:REACT_99457 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Arabidopsis thaliana"
xref: RHEA:14920
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
is_a: GO:0032451 ! demethylase activity
AmiGO
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