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Category:GO:0008396 ! oxysterol 7-alpha-hydroxylase activity
name: oxysterol 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791]
synonym: "cytochrome P450 CYP7B1" NARROW []
xref: Reactome:REACT_10066 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Homo sapiens"
xref: Reactome:REACT_102623 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Sus scrofa"
xref: Reactome:REACT_104165 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Bos taurus"
xref: Reactome:REACT_106509 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Taeniopygia guttata"
xref: Reactome:REACT_106965 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Gallus gallus"
xref: Reactome:REACT_107334 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Mus musculus"
xref: Reactome:REACT_109790 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Bos taurus"
xref: Reactome:REACT_112158 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Dictyostelium discoideum"
xref: Reactome:REACT_112291 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Oryza sativa"
xref: Reactome:REACT_112636 "27-hydroxycholesterol is 7alpha-hydroxylated, Arabidopsis thaliana"
xref: Reactome:REACT_112857 "27-hydroxycholesterol is 7alpha-hydroxylated, Dictyostelium discoideum"
xref: Reactome:REACT_113559 "27-hydroxycholesterol is 7alpha-hydroxylated, Oryza sativa"
xref: Reactome:REACT_113710 "27-hydroxycholesterol is 7alpha-hydroxylated, Mycobacterium tuberculosis"
xref: Reactome:REACT_114515 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Dictyostelium discoideum"
xref: Reactome:REACT_114585 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Arabidopsis thaliana"
xref: Reactome:REACT_114797 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Arabidopsis thaliana"
xref: Reactome:REACT_114849 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Mycobacterium tuberculosis"
xref: Reactome:REACT_115480 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Oryza sativa"
xref: Reactome:REACT_115504 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Mycobacterium tuberculosis"
xref: Reactome:REACT_30004 "27-hydroxycholesterol is 7alpha-hydroxylated, Mus musculus"
xref: Reactome:REACT_30911 "27-hydroxycholesterol is 7alpha-hydroxylated, Rattus norvegicus"
xref: Reactome:REACT_30974 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Sus scrofa"
xref: Reactome:REACT_31217 "27-hydroxycholesterol is 7alpha-hydroxylated, Taeniopygia guttata"
xref: Reactome:REACT_32313 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Mus musculus"
xref: Reactome:REACT_32758 "27-hydroxycholesterol is 7alpha-hydroxylated, Gallus gallus"
xref: Reactome:REACT_33058 "27-hydroxycholesterol is 7alpha-hydroxylated, Sus scrofa"
xref: Reactome:REACT_34312 "27-hydroxycholesterol is 7alpha-hydroxylated, Xenopus tropicalis"
xref: Reactome:REACT_34380 "27-hydroxycholesterol is 7alpha-hydroxylated, Danio rerio"
xref: Reactome:REACT_83366 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Danio rerio"
xref: Reactome:REACT_84538 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Canis familiaris"
xref: Reactome:REACT_88255 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Taeniopygia guttata"
xref: Reactome:REACT_90870 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Rattus norvegicus"
xref: Reactome:REACT_91006 "27-hydroxycholesterol is 7alpha-hydroxylated, Canis familiaris"
xref: Reactome:REACT_93049 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Canis familiaris"
xref: Reactome:REACT_93832 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Rattus norvegicus"
xref: Reactome:REACT_96224 "27-hydroxycholesterol is 7alpha-hydroxylated, Bos taurus"
xref: Reactome:REACT_96813 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Gallus gallus"
xref: Reactome:REACT_96977 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Danio rerio"
xref: Reactome:REACT_97910 "24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, Xenopus tropicalis"
xref: Reactome:REACT_9950 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Homo sapiens"
xref: Reactome:REACT_99618 "25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1, Xenopus tropicalis"
xref: Reactome:REACT_9994 "27-hydroxycholesterol is 7alpha-hydroxylated, Homo sapiens"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
AmiGO
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