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Category:GO:0008386 ! cholesterol monooxygenase (side-chain-cleaving) activity
name: cholesterol monooxygenase (side-chain-cleaving) activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6]
synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6]
synonym: "cholesterol 20-22-desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol C(20-22) desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol C20-22 desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" EXACT [EC:1.14.15.6]
synonym: "Cyp11a1" NARROW []
synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6]
synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6]
synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6]
synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6]
synonym: "desmolase, steroid 20-22" EXACT [EC:1.14.15.6]
synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6]
synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6]
synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6]
xref: EC:1.14.15.6
xref: MetaCyc:1.14.15.6-RXN
xref: Reactome:REACT_10035 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Homo sapiens"
xref: Reactome:REACT_10084 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Homo sapiens"
xref: Reactome:REACT_101443 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Xenopus tropicalis"
xref: Reactome:REACT_101702 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Canis familiaris"
xref: Reactome:REACT_102228 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Canis familiaris"
xref: Reactome:REACT_102567 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Mus musculus"
xref: Reactome:REACT_103083 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Mus musculus"
xref: Reactome:REACT_105259 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Gallus gallus"
xref: Reactome:REACT_106318 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Bos taurus"
xref: Reactome:REACT_108193 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Bos taurus"
xref: Reactome:REACT_109534 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Danio rerio"
xref: Reactome:REACT_109733 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Rattus norvegicus"
xref: Reactome:REACT_109882 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Drosophila melanogaster"
xref: Reactome:REACT_65089 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Bos taurus"
xref: Reactome:REACT_81340 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Danio rerio"
xref: Reactome:REACT_82060 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Canis familiaris"
xref: Reactome:REACT_82162 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Taeniopygia guttata"
xref: Reactome:REACT_83052 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Xenopus tropicalis"
xref: Reactome:REACT_83084 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Mus musculus"
xref: Reactome:REACT_83609 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Gallus gallus"
xref: Reactome:REACT_83756 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Xenopus tropicalis"
xref: Reactome:REACT_85511 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Rattus norvegicus"
xref: Reactome:REACT_87922 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Drosophila melanogaster"
xref: Reactome:REACT_88900 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Rattus norvegicus"
xref: Reactome:REACT_89556 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Drosophila melanogaster"
xref: Reactome:REACT_90435 "20alpha,22beta-hydroxycholesterol is cleaved by CYP11A1 to yield pregnenolone and isocaproaldehyde, Danio rerio"
xref: Reactome:REACT_92023 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Taeniopygia guttata"
xref: Reactome:REACT_94232 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Gallus gallus"
xref: Reactome:REACT_94560 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol, Taeniopygia guttata"
xref: Reactome:REACT_9956 "Oxidation of cholesterol to 22beta-hydroxycholesterol, Homo sapiens"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
AmiGO
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