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Category:GO:0008119 ! thiopurine S-methyltransferase activity
name: thiopurine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67]
subset: gosubset_prok
synonym: "6-thiopurine transmethylase activity" EXACT [EC:2.1.1.67]
synonym: "mercaptopurine methyltransferase activity" EXACT [EC:2.1.1.67]
synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" EXACT [EC:2.1.1.67]
synonym: "thiopurine methyltransferase activity" EXACT [EC:2.1.1.67]
synonym: "TPMT" RELATED [EC:2.1.1.67]
xref: EC:2.1.1.67
xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN
xref: Reactome:REACT_102303 "6-mercaptopurine can be S-methylated, Bos taurus"
xref: Reactome:REACT_103452 "6-mercaptopurine can be S-methylated, Danio rerio"
xref: Reactome:REACT_29153 "6-mercaptopurine can be S-methylated, Gallus gallus"
xref: Reactome:REACT_29397 "6-mercaptopurine can be S-methylated, Taeniopygia guttata"
xref: Reactome:REACT_30624 "6-mercaptopurine can be S-methylated, Sus scrofa"
xref: Reactome:REACT_6779 "6-mercaptopurine can be S-methylated, Homo sapiens"
xref: Reactome:REACT_78026 "6-mercaptopurine can be S-methylated, Canis familiaris"
xref: Reactome:REACT_89240 "6-mercaptopurine can be S-methylated, Xenopus tropicalis"
xref: Reactome:REACT_94803 "6-mercaptopurine can be S-methylated, Rattus norvegicus"
xref: Reactome:REACT_99400 "6-mercaptopurine can be S-methylated, Mus musculus"
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
AmiGO
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