Category:GO:0007259 ! JAK-STAT cascade

name: JAK-STAT cascade
namespace: biological_process
def: "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028]
is_a: GO:0007243 ! intracellular protein kinase cascade

AmiGO

Child Terms

This term has the following 8 child terms, out of 8 total.

• [+] GO:0007260 ! tyrosine phosphorylation of STAT protein (10)
• [  ] GO:0007261 ! JAK-induced STAT protein dimerization
• [+] GO:0007262 ! STAT protein import into nucleus (3)
• [  ] GO:0007262 ! STAT protein nuclear translocation
• [+] GO:0046425 ! regulation of JAK-STAT cascade (6)
• [+] GO:0046426 ! negative regulation of JAK-STAT cascade (2)
• [+] GO:0046427 ! positive regulation of JAK-STAT cascade (3)
• [  ] GO:0060397 ! JAK-STAT cascade involved in growth hormone signaling pathway

Pages in category "GO:0007259 ! JAK-STAT cascade"

The following 49 pages are in this category, out of 49 total.