Category:GO:0007254 ! JNK cascade

name: JNK cascade
namespace: biological_process
def: "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974]
synonym: "c-Jun N-terminal kinase cascade" EXACT [PMID:20811974]
synonym: "JNK1 cascade" NARROW [GOC:add]
synonym: "JNK2 cascade" NARROW [GOC:add]
synonym: "JNK3 cascade" NARROW [GOC:add]
synonym: "MAPK10 cascade" NARROW [GOC:add]
synonym: "MAPK8 cascade" NARROW [GOC:add]
synonym: "MAPK9 cascade" NARROW [GOC:add]
synonym: "SAPK cascade" BROAD []
synonym: "stress-activated protein kinase cascade" BROAD []
xref: Reactome:REACT_107073 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Danio rerio"
xref: Reactome:REACT_107433 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Taeniopygia guttata"
xref: Reactome:REACT_112172 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Arabidopsis thaliana"
xref: Reactome:REACT_114741 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Oryza sativa"
xref: Reactome:REACT_114745 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Dictyostelium discoideum"
xref: Reactome:REACT_21368 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Homo sapiens"
xref: Reactome:REACT_28804 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Canis familiaris"
xref: Reactome:REACT_29903 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Bos taurus"
xref: Reactome:REACT_29906 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Mus musculus"
xref: Reactome:REACT_32441 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Sus scrofa"
xref: Reactome:REACT_79447 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Xenopus tropicalis"
xref: Reactome:REACT_87936 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Gallus gallus"
xref: Reactome:REACT_89698 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Rattus norvegicus"
xref: Reactome:REACT_95448 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Caenorhabditis elegans"
is_a: GO:0051403 ! stress-activated MAPK cascade

AmiGO

Child Terms

This term has the following 7 child terms, out of 7 total.

• [  ] GO:0007256 ! activation of JNKK activity
• [  ] GO:0007257 ! activation of JUN kinase activity
• [  ] GO:0007258 ! JUN phosphorylation
• [  ] GO:0042655 ! activation of JNKKK activity
• [+] GO:0046328 ! regulation of JNK cascade (3)
• [  ] GO:0046329 ! negative regulation of JNK cascade
• [  ] GO:0046330 ! positive regulation of JNK cascade

Pages in category "GO:0007254 ! JNK cascade"

The following 88 pages are in this category, out of 88 total.