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Category:GO:0007252 ! I-kappaB phosphorylation
name: I-kappaB phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:21772278, PMID:7594468]
synonym: "IkappaB phosphorylation" EXACT [GOC:bf]
synonym: "IKB phosphorylation" EXACT [GOC:bf]
synonym: "inhibitor of kappaB phosphorylation" EXACT [GOC:bf]
synonym: "inhibitor of NF-kappaB phosphorylation" EXACT [GOC:bf]
is_a: GO:0006468 ! protein phosphorylation
relationship:part_of: GO:0007249 ! I-kappaB kinase/NF-kappaB cascade
AmiGO
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