Category:GO:0007249 ! I-kappaB kinase/NF-kappaB cascade

name: I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:12773372, Reactome:REACT_13696.1]
synonym: "activation of the inhibitor of kappa kinase" RELATED []
synonym: "canonical NF-kappaB signaling cascade" EXACT [GOC:bf]
synonym: "NF-kappaB cascade" BROAD []
synonym: "p50-dependent NF-kappaB signaling" RELATED [PMID:18292232]
xref: Reactome:REACT_13696.1 "NF-kB is activated and signals survival, Homo sapiens"
xref: Reactome:REACT_25351 "TRAF6 mediated induction of TAK1 complex, Homo sapiens"
is_a: GO:0007243 ! intracellular protein kinase cascade

AmiGO

Child Terms

This term has the following 6 child terms, out of 6 total.

• [  ] GO:0007252 ! I-kappaB phosphorylation
• [  ] GO:0008588 ! release of cytoplasmic sequestered NF-kappaB
• [+] GO:0042348 ! NF-kappaB import into nucleus (3)
• [+] GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB cascade (3)
• [+] GO:0043123 ! positive regulation of I-kappaB kinase/NF-kappaB cascade (1)
• [+] GO:0043124 ! negative regulation of I-kappaB kinase/NF-kappaB cascade (2)

Pages in category "GO:0007249 ! I-kappaB kinase/NF-kappaB cascade"

The following 40 pages are in this category, out of 40 total.