Category:GO:0006915 ! apoptosis

name: apoptosis
namespace: biological_process
alt_id:GO:0008632
def: "A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
synonym: "apoptotic cell death" EXACT [GOC:sl]
synonym: "apoptotic program" NARROW [GOC:add]
synonym: "apoptotic programmed cell death" EXACT []
synonym: "programmed cell death by apoptosis" EXACT []
synonym: "signaling (initiator) caspase activity" RELATED []
synonym: "type I programmed cell death" NARROW []
xref: Reactome:REACT_100045 "Apoptosis, Drosophila melanogaster"
xref: Reactome:REACT_100962 "Apoptosis, Mus musculus"
xref: Reactome:REACT_101249 "NRIF signals cell death from the nucleus, Danio rerio"
xref: Reactome:REACT_104187 "NRAGE signals death through JNK, Taeniopygia guttata"
xref: Reactome:REACT_105149 "NADE modulates death signalling, Rattus norvegicus"
xref: Reactome:REACT_106405 "NRAGE signals death through JNK, Xenopus tropicalis"
xref: Reactome:REACT_106672 "NADE modulates death signalling, Sus scrofa"
xref: Reactome:REACT_107264 "NRIF signals cell death from the nucleus, Xenopus tropicalis"
xref: Reactome:REACT_108651 "NRAGE signals death through JNK, Mus musculus"
xref: Reactome:REACT_109165 "NRAGE signals death through JNK, Arabidopsis thaliana"
xref: Reactome:REACT_110081 "NRAGE signals death through JNK, Schizosaccharomyces pombe"
xref: Reactome:REACT_111964 "NRAGE signals death through JNK, Dictyostelium discoideum"
xref: Reactome:REACT_13526 "NADE modulates death signalling, Homo sapiens"
xref: Reactome:REACT_13638 "NRAGE signals death through JNK, Homo sapiens"
xref: Reactome:REACT_13643 "NRIF signals cell death from the nucleus, Homo sapiens"
xref: Reactome:REACT_28087 "Apoptosis, Saccharomyces cerevisiae"
xref: Reactome:REACT_28795 "Apoptosis, Oryza sativa"
xref: Reactome:REACT_28816 "Apoptosis, Danio rerio"
xref: Reactome:REACT_30266 "Apoptosis, Arabidopsis thaliana"
xref: Reactome:REACT_30361 "Apoptosis, Canis familiaris"
xref: Reactome:REACT_30371 "NRAGE signals death through JNK, Saccharomyces cerevisiae"
xref: Reactome:REACT_30548 "NRAGE signals death through JNK, Caenorhabditis elegans"
xref: Reactome:REACT_30763 "NRAGE signals death through JNK, Oryza sativa"
xref: Reactome:REACT_31349 "NRAGE signals death through JNK, Canis familiaris"
xref: Reactome:REACT_34139 "NRAGE signals death through JNK, Gallus gallus"
xref: Reactome:REACT_578 "Apoptosis, Homo sapiens"
xref: Reactome:REACT_77132 "NRAGE signals death through JNK, Drosophila melanogaster"
xref: Reactome:REACT_77313 "NADE modulates death signalling, Bos taurus"
xref: Reactome:REACT_77415 "NRIF signals cell death from the nucleus, Canis familiaris"
xref: Reactome:REACT_78287 "Apoptosis, Gallus gallus"
xref: Reactome:REACT_78802 "NADE modulates death signalling, Canis familiaris"
xref: Reactome:REACT_79809 "Apoptosis, Schizosaccharomyces pombe"
xref: Reactome:REACT_82724 "Apoptosis, Taeniopygia guttata"
xref: Reactome:REACT_83328 "Apoptosis, Sus scrofa"
xref: Reactome:REACT_85877 "NRAGE signals death through JNK, Rattus norvegicus"
xref: Reactome:REACT_86749 "Apoptosis, Rattus norvegicus"
xref: Reactome:REACT_86873 "NRIF signals cell death from the nucleus, Gallus gallus"
xref: Reactome:REACT_87570 "NRIF signals cell death from the nucleus, Rattus norvegicus"
xref: Reactome:REACT_88740 "NRIF signals cell death from the nucleus, Sus scrofa"
xref: Reactome:REACT_88784 "NRIF signals cell death from the nucleus, Mus musculus"
xref: Reactome:REACT_89196 "Apoptosis, Dictyostelium discoideum"
xref: Reactome:REACT_90267 "NRIF signals cell death from the nucleus, Taeniopygia guttata"
xref: Reactome:REACT_91011 "Apoptosis, Caenorhabditis elegans"
xref: Reactome:REACT_91243 "NADE modulates death signalling, Mus musculus"
xref: Reactome:REACT_93937 "Apoptosis, Bos taurus"
xref: Reactome:REACT_94099 "NRAGE signals death through JNK, Danio rerio"
xref: Reactome:REACT_95069 "Apoptosis, Xenopus tropicalis"
xref: Reactome:REACT_95675 "Apoptosis, Plasmodium falciparum"
xref: Reactome:REACT_97627 "NRIF signals cell death from the nucleus, Bos taurus"
xref: Reactome:REACT_99784 "NRAGE signals death through JNK, Bos taurus"
xref: Reactome:REACT_99799 "NRAGE signals death through JNK, Sus scrofa"
xref: Wikipedia:Apoptosis
is_a: GO:0012501 ! programmed cell death

AmiGO

Child Terms

This term has the following 8 child terms, out of 8 total.

• [+] GO:0006919 ! activation of caspase activity (2)
• [+] GO:0006921 ! cell structure disassembly during apoptosis (2)
• [  ] GO:0030262 ! apoptotic nuclear changes
• [+] GO:0042981 ! regulation of apoptosis (7)
• [+] GO:0043065 ! positive regulation of apoptosis (1)
• [+] GO:0043066 ! negative regulation of apoptosis (1)
• [  ] GO:0061364 ! apoptosis involved in luteolysis
• [+] GO:0071839 ! apoptosis in bone marrow (2)

Pages in category "GO:0006915 ! apoptosis"

The following 200 pages are in this category, out of 433 total.