Category:GO:0005089 ! Rho guanyl-nucleotide exchange factor activity

name: Rho guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
synonym: "Rho guanine nucleotide exchange factor" EXACT []
synonym: "RhoGEF" EXACT []
xref: Reactome:REACT_100152 "Activation of Rac1, Xenopus tropicalis"
xref: Reactome:REACT_100689 "Activation of Rho by LARG and PDZ-RhoGEF, Sus scrofa"
xref: Reactome:REACT_100721 "GEFs activate Rho GTPase:GDP, Schizosaccharomyces pombe"
xref: Reactome:REACT_10098 "GEFs activate Rho GTPase:GDP, Homo sapiens"
xref: Reactome:REACT_100998 "Activation of Cdc42, Caenorhabditis elegans"
xref: Reactome:REACT_101393 "GEFs activate RhoA,B,C, Mus musculus"
xref: Reactome:REACT_103139 "Activation of Rho by LARG and PDZ-RhoGEF, Rattus norvegicus"
xref: Reactome:REACT_103592 "GEFs activate Rho GTPase:GDP, Caenorhabditis elegans"
xref: Reactome:REACT_103724 "Activation of Cdc42, Bos taurus"
xref: Reactome:REACT_105214 "Activation of Cdc42, Rattus norvegicus"
xref: Reactome:REACT_105608 "GEFs activate RhoA,B,C, Canis familiaris"
xref: Reactome:REACT_106134 "GEFs activate RhoA,B,C, Dictyostelium discoideum"
xref: Reactome:REACT_108126 "GEFs activate RhoA,B,C, Gallus gallus"
xref: Reactome:REACT_108320 "Activation of Rho by LARG and PDZ-RhoGEF, Xenopus tropicalis"
xref: Reactome:REACT_108721 "GEFs activate Rho GTPase:GDP, Mus musculus"
xref: Reactome:REACT_108759 "Activation of Rho by LARG and PDZ-RhoGEF, Mus musculus"
xref: Reactome:REACT_109052 "GEFs activate Rho GTPase:GDP, Danio rerio"
xref: Reactome:REACT_109265 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Caenorhabditis elegans"
xref: Reactome:REACT_109689 "GEFs activate RhoA,B,C, Rattus norvegicus"
xref: Reactome:REACT_112014 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Danio rerio"
xref: Reactome:REACT_114452 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Xenopus tropicalis"
xref: Reactome:REACT_114487 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Rattus norvegicus"
xref: Reactome:REACT_13808 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Homo sapiens"
xref: Reactome:REACT_19137 "Activation of Rho by LARG and PDZ-RhoGEF, Homo sapiens"
xref: Reactome:REACT_19216 "GEFs activate RhoA,B,C, Homo sapiens"
xref: Reactome:REACT_22200 "Activation of Rac1, Homo sapiens"
xref: Reactome:REACT_22281 "Activation of Cdc42, Homo sapiens"
xref: Reactome:REACT_28825 "Activation of Rho by LARG and PDZ-RhoGEF, Gallus gallus"
xref: Reactome:REACT_28967 "GEFs activate Rho GTPase:GDP, Sus scrofa"
xref: Reactome:REACT_30773 "GEFs activate Rho GTPase:GDP, Saccharomyces cerevisiae"
xref: Reactome:REACT_30791 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Canis familiaris"
xref: Reactome:REACT_31433 "GEFs activate RhoA,B,C, Xenopus tropicalis"
xref: Reactome:REACT_31965 "Activation of Rac1, Rattus norvegicus"
xref: Reactome:REACT_32024 "Activation of Rho by LARG and PDZ-RhoGEF, Bos taurus"
xref: Reactome:REACT_32371 "GEFs activate Rho GTPase:GDP, Dictyostelium discoideum"
xref: Reactome:REACT_34520 "Activation of Rac1, Mus musculus"
xref: Reactome:REACT_77383 "GEFs activate RhoA,B,C, Bos taurus"
xref: Reactome:REACT_77389 "GEFs activate RhoA,B,C, Sus scrofa"
xref: Reactome:REACT_77531 "GEFs activate Rho GTPase:GDP, Oryza sativa"
xref: Reactome:REACT_79833 "GEFs activate Rho GTPase:GDP, Rattus norvegicus"
xref: Reactome:REACT_81313 "Activation of Rho by LARG and PDZ-RhoGEF, Danio rerio"
xref: Reactome:REACT_82885 "Activation of Rho by LARG and PDZ-RhoGEF, Taeniopygia guttata"
xref: Reactome:REACT_82970 "GEFs activate Rho GTPase:GDP, Taeniopygia guttata"
xref: Reactome:REACT_84523 "Activation of Cdc42, Mus musculus"
xref: Reactome:REACT_85048 "GEFs activate RhoA,B,C, Taeniopygia guttata"
xref: Reactome:REACT_86070 "GEFs activate RhoA,B,C, Caenorhabditis elegans"
xref: Reactome:REACT_87646 "GEFs activate Rho GTPase:GDP, Xenopus tropicalis"
xref: Reactome:REACT_88315 "GEFs activate Rho GTPase:GDP, Bos taurus"
xref: Reactome:REACT_91703 "GEFs activate Rho GTPase:GDP, Canis familiaris"
xref: Reactome:REACT_92249 "Activation of Rac1, Canis familiaris"
xref: Reactome:REACT_92606 "Activation of Cdc42, Danio rerio"
xref: Reactome:REACT_92645 "GEFs activate Rho GTPase:GDP, Drosophila melanogaster"
xref: Reactome:REACT_93562 "Activation of Cdc42, Xenopus tropicalis"
xref: Reactome:REACT_94383 "GEFs activate RhoA,B,C, Danio rerio"
xref: Reactome:REACT_94512 "GEFs activate RhoA,B,C, Drosophila melanogaster"
xref: Reactome:REACT_95084 "GEFs activate RhoA,B,C, Saccharomyces cerevisiae"
xref: Reactome:REACT_95178 "GEFs activate RhoA,B,C, Schizosaccharomyces pombe"
xref: Reactome:REACT_95796 "Activation of Rac1, Danio rerio"
xref: Reactome:REACT_96171 "Activation of Rac1, Drosophila melanogaster"
xref: Reactome:REACT_96181 "Activation of Cdc42, Sus scrofa"
xref: Reactome:REACT_96227 "GEFs activate Rho GTPase:GDP, Arabidopsis thaliana"
xref: Reactome:REACT_96803 "Activation of Rho by LARG and PDZ-RhoGEF, Canis familiaris"
xref: Reactome:REACT_97069 "Activation of Rac1, Bos taurus"
xref: Reactome:REACT_97117 "Activation of Cdc42, Drosophila melanogaster"
xref: Reactome:REACT_97788 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Bos taurus"
xref: Reactome:REACT_98631 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Drosophila melanogaster"
xref: Reactome:REACT_98998 "GEFs activate Rho GTPase:GDP, Gallus gallus"
xref: Reactome:REACT_99425 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Mus musculus"
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

AmiGO

Child Terms

This term has only the following child term.

• [  ] GO:0030676 ! Rac guanyl-nucleotide exchange factor activity

Pages in category "GO:0005089 ! Rho guanyl-nucleotide exchange factor activity"

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