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Category:GO:0004852 ! uroporphyrinogen-III synthase activity
name: uroporphyrinogen-III synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18968]
subset: gosubset_prok
synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" EXACT [EC:4.2.1.75]
synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" EXACT [EC:4.2.1.75]
synonym: "porphobilinogenase activity" EXACT [EC:4.2.1.75]
synonym: "URO-synthase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen III cosynthase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen isomerase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen-III cosynthase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen-III cosynthetase activity" EXACT [EC:4.2.1.75]
xref: EC:4.2.1.75
xref: KEGG:R03165
xref: MetaCyc:UROGENIIISYN-RXN
xref: Reactome:REACT_102458 "Conversion of HMB to uroporphyrinogen III, Drosophila melanogaster"
xref: Reactome:REACT_102627 "Conversion of HMB to uroporphyrinogen III, Sus scrofa"
xref: Reactome:REACT_104364 "Conversion of HMB to uroporphyrinogen III, Canis familiaris"
xref: Reactome:REACT_104957 "Conversion of HMB to uroporphyrinogen III, Rattus norvegicus"
xref: Reactome:REACT_116029 "hydroxymethylbilane => uroporphyrinogen III + H2O, Gallus gallus"
xref: Reactome:REACT_28073 "Conversion of HMB to uroporphyrinogen III, Bos taurus"
xref: Reactome:REACT_33499 "Conversion of HMB to uroporphyrinogen III, Gallus gallus"
xref: Reactome:REACT_77260 "Conversion of HMB to uroporphyrinogen III, Saccharomyces cerevisiae"
xref: Reactome:REACT_81186 "Conversion of HMB to uroporphyrinogen III, Schizosaccharomyces pombe"
xref: Reactome:REACT_82801 "Conversion of HMB to uroporphyrinogen III, Mus musculus"
xref: Reactome:REACT_84413 "Conversion of HMB to uroporphyrinogen III, Xenopus tropicalis"
xref: Reactome:REACT_92101 "Conversion of HMB to uroporphyrinogen III, Taeniopygia guttata"
xref: Reactome:REACT_9526 "Conversion of HMB to uroporphyrinogen III, Homo sapiens"
xref: Reactome:REACT_99974 "Conversion of HMB to uroporphyrinogen III, Danio rerio"
xref: RHEA:18968
is_a: GO:0016836 ! hydro-lyase activity
AmiGO
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