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Category:GO:0004839 ! ubiquitin activating enzyme activity
name: ubiquitin activating enzyme activity
namespace: molecular_function
def: "Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme]
comment: The ubiquitin activating enzyme catalyzes a ligation reaction.
synonym: "E1 ubiquitin-activating enzyme" RELATED [EC:6.2.1.45]
xref: EC:6.2.1.45
is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity
relationship: part_of: GO:0016567 ! protein ubiquitination
AmiGO
<GOterm>GO:0004839</GOterm>
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