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Category:GO:0004800 ! thyroxine 5'-deiodinase activity
name: thyroxine 5'-deiodinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.97.1.10]
comment: Note that this was EC:3.8.1.4.
synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" EXACT [EC:1.97.1.10]
synonym: "diiodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10]
synonym: "iodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10]
synonym: "iodothyronine outer ring monodeiodinase activity" EXACT [EC:1.97.1.10]
synonym: "L-thyroxine iodohydrolase (reducing) activity" EXACT [EC:1.97.1.10]
synonym: "outer ring-deiodinating pathway" EXACT [PMID:20403357]
synonym: "thyroxine 5' deiodinase activity" EXACT []
synonym: "thyroxine deiodinase activity" BROAD []
synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.97.1.10]
synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.97.1.10]
xref: EC:1.97.1.10
xref: MetaCyc:THYROXINE-DEIODINASE-RXN
xref: Reactome:REACT_101070 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Taeniopygia guttata"
xref: Reactome:REACT_106668 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Bos taurus"
xref: Reactome:REACT_15469 "Thyroxine is deiodinated to triiodothyronine, Homo sapiens"
xref: Reactome:REACT_15528 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Homo sapiens"
xref: Reactome:REACT_29089 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Sus scrofa"
xref: Reactome:REACT_30839 "Thyroxine is deiodinated to triiodothyronine, Bos taurus"
xref: Reactome:REACT_32482 "Thyroxine is deiodinated to triiodothyronine, Rattus norvegicus"
xref: Reactome:REACT_77772 "Thyroxine is deiodinated to triiodothyronine, Gallus gallus"
xref: Reactome:REACT_81783 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Gallus gallus"
xref: Reactome:REACT_81828 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Mus musculus"
xref: Reactome:REACT_83155 "Thyroxine is deiodinated to triiodothyronine, Taeniopygia guttata"
xref: Reactome:REACT_85931 "Thyroxine is deiodinated to triiodothyronine, Mus musculus"
xref: Reactome:REACT_87369 "Thyroxine is deiodinated to triiodothyronine, Canis familiaris"
xref: Reactome:REACT_91419 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Xenopus tropicalis"
xref: Reactome:REACT_93038 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Dictyostelium discoideum"
xref: Reactome:REACT_97119 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Canis familiaris"
xref: Reactome:REACT_98784 "Thyroxine is deiodinated to reverse triiodothyronine (RT3), Danio rerio"
xref: Reactome:REACT_99112 "Thyroxine is deiodinated to triiodothyronine, Danio rerio"
xref: Reactome:REACT_99930 "Thyroxine is deiodinated to triiodothyronine, Dictyostelium discoideum"
xref: RHEA:19748
is_a: GO:0016491 ! oxidoreductase activity
AmiGO
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