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Category:GO:0004748 ! ribonucleoside-diphosphate reductase activity
name: ribonucleoside-diphosphate reductase activity
namespace: molecular_function
alt_id:GO:0016959
alt_id:GO:0016960
alt_id:GO:0016961
def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1]
subset: gosubset_prok
synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.1]
synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.1]
synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" EXACT []
synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" EXACT []
synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" EXACT []
synonym: "class I ribonucleotide reductase activity" EXACT []
synonym: "class II ribonucleoside-diphosphate reductase activity" EXACT []
synonym: "class II ribonucleotide reductase activity" EXACT []
synonym: "class III ribonucleotide reductase activity" EXACT []
synonym: "nucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1]
synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED []
synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT [EC:1.17.4.1]
synonym: "ribonucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1]
synonym: "ribonucleotide diphosphate reductase activity" EXACT [EC:1.17.4.1]
synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.1]
synonym: "RNR" EXACT []
xref: EC:1.17.4.1
xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN
xref: Reactome:REACT_100706 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Xenopus tropicalis"
xref: Reactome:REACT_101277 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Mus musculus"
xref: Reactome:REACT_101834 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Xenopus tropicalis"
xref: Reactome:REACT_103240 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Mus musculus"
xref: Reactome:REACT_104003 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Gallus gallus"
xref: Reactome:REACT_107455 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Bos taurus"
xref: Reactome:REACT_108099 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Gallus gallus"
xref: Reactome:REACT_113565 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_115326 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_2182 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Homo sapiens"
xref: Reactome:REACT_29224 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Sus scrofa"
xref: Reactome:REACT_30318 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Taeniopygia guttata"
xref: Reactome:REACT_30508 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Gallus gallus"
xref: Reactome:REACT_31147 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_31478 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Canis familiaris"
xref: Reactome:REACT_33931 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Danio rerio"
xref: Reactome:REACT_34006 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Bos taurus"
xref: Reactome:REACT_375 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Homo sapiens"
xref: Reactome:REACT_642 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Homo sapiens"
xref: Reactome:REACT_79772 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Mus musculus"
xref: Reactome:REACT_81191 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Bos taurus"
xref: Reactome:REACT_83827 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Canis familiaris"
xref: Reactome:REACT_85022 "NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O, Danio rerio"
xref: Reactome:REACT_86582 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Xenopus tropicalis"
xref: Reactome:REACT_91454 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Canis familiaris"
xref: Reactome:REACT_94107 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Taeniopygia guttata"
xref: Reactome:REACT_98694 "NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O, Danio rerio"
xref: RHEA:23255
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
AmiGO
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