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Category:GO:0004722 ! protein serine/threonine phosphatase activity
name: protein serine/threonine phosphatase activity
namespace: molecular_function
alt_id:GO:0000158
alt_id:GO:0000163
alt_id:GO:0008598
alt_id:GO:0008600
alt_id:GO:0015071
alt_id:GO:0030357
alt_id:GO:0030358
alt_id:GO:0030360
alt_id:GO:0030361
def: "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]
subset: gosubset_prok
synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16]
synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16]
synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16]
synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16]
synonym: "calcineurin" NARROW []
synonym: "casein phosphatase" NARROW [EC:3.1.3.16]
synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16]
synonym: "phosphatase 2A" NARROW [EC:3.1.3.16]
synonym: "phosphatase 2B" NARROW [EC:3.1.3.16]
synonym: "phosphatase C-II" NARROW [EC:3.1.3.16]
synonym: "phosphatase H-II" NARROW [EC:3.1.3.16]
synonym: "phosphatase I" NARROW [EC:3.1.3.16]
synonym: "phosphatase IB" NARROW [EC:3.1.3.16]
synonym: "phosphatase II" NARROW [EC:3.1.3.16]
synonym: "phosphatase III" NARROW [EC:3.1.3.16]
synonym: "phosphatase IV" NARROW [EC:3.1.3.16]
synonym: "phosphatase SP" NARROW [EC:3.1.3.16]
synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16]
synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16]
synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16]
synonym: "protein D phosphatase" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase type 1 activity" NARROW []
synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase type 2A activity" NARROW []
synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase type 2B activity" NARROW []
synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase type 2C activity" NARROW []
synonym: "protein phosphatase type 4 activity" NARROW []
synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase X" NARROW []
synonym: "serine/threonine specific protein phosphatase activity" EXACT []
xref: Reactome:REACT_102328 "AMPK is dephosphorylated, Gallus gallus"
xref: Reactome:REACT_103273 "AMPK is dephosphorylated, Danio rerio"
xref: Reactome:REACT_104935 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_105168 "ERKs are inactivated by protein phosphatase 2A, Bos taurus"
xref: Reactome:REACT_105744 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Gallus gallus"
xref: Reactome:REACT_106758 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_108076 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Sus scrofa"
xref: Reactome:REACT_108095 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Danio rerio"
xref: Reactome:REACT_109701 "AMPK is dephosphorylated, Caenorhabditis elegans"
xref: Reactome:REACT_110128 "AMPK is dephosphorylated, Sus scrofa"
xref: Reactome:REACT_111094 "PPA2A dephosphorylates SPRY2, Homo sapiens"
xref: Reactome:REACT_112525 "PHLPP dephosphorylates S473 in AKT, Gallus gallus"
xref: Reactome:REACT_112659 "AMPK is dephosphorylated, Saccharomyces cerevisiae"
xref: Reactome:REACT_113935 "PHLPP dephosphorylates S473 in AKT, Xenopus tropicalis"
xref: Reactome:REACT_114990 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Xenopus tropicalis"
xref: Reactome:REACT_116150 "PP2B dephosphorylates DARPP-32 on T34, Rattus norvegicus"
xref: Reactome:REACT_12403 "PHLPP dephosphorylates S473 in AKT, Homo sapiens"
xref: Reactome:REACT_12539 "ERKs are inactivated by protein phosphatase 2A, Homo sapiens"
xref: Reactome:REACT_15438 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Homo sapiens"
xref: Reactome:REACT_15494 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Homo sapiens"
xref: Reactome:REACT_1705 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Rattus norvegicus"
xref: Reactome:REACT_19304 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Homo sapiens"
xref: Reactome:REACT_21418 "AMPK is dephosphorylated, Homo sapiens"
xref: Reactome:REACT_29362 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Rattus norvegicus"
xref: Reactome:REACT_30903 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Canis familiaris"
xref: Reactome:REACT_31424 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Bos taurus"
xref: Reactome:REACT_31944 "AMPK is dephosphorylated, Taeniopygia guttata"
xref: Reactome:REACT_32258 "ERKs are inactivated by protein phosphatase 2A, Taeniopygia guttata"
xref: Reactome:REACT_33433 "PHLPP dephosphorylates S473 in AKT, Rattus norvegicus"
xref: Reactome:REACT_33609 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Mus musculus"
xref: Reactome:REACT_403 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Homo sapiens"
xref: Reactome:REACT_60521 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Sus scrofa"
xref: Reactome:REACT_75794 "Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex, Homo sapiens"
xref: Reactome:REACT_77118 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Bos taurus"
xref: Reactome:REACT_77285 "PHLPP dephosphorylates S473 in AKT, Drosophila melanogaster"
xref: Reactome:REACT_77773 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Bos taurus"
xref: Reactome:REACT_79893 "AMPK is dephosphorylated, Drosophila melanogaster"
xref: Reactome:REACT_80418 "PHLPP dephosphorylates S473 in AKT, Taeniopygia guttata"
xref: Reactome:REACT_81032 "ERKs are inactivated by protein phosphatase 2A, Dictyostelium discoideum"
xref: Reactome:REACT_82252 "AMPK is dephosphorylated, Mus musculus"
xref: Reactome:REACT_82455 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Taeniopygia guttata"
xref: Reactome:REACT_82736 "ERKs are inactivated by protein phosphatase 2A, Mus musculus"
xref: Reactome:REACT_82848 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Danio rerio"
xref: Reactome:REACT_83123 "AMPK is dephosphorylated, Canis familiaris"
xref: Reactome:REACT_84149 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Canis familiaris"
xref: Reactome:REACT_84173 "AMPK is dephosphorylated, Rattus norvegicus"
xref: Reactome:REACT_87477 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_87535 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Mus musculus"
xref: Reactome:REACT_87738 "ERKs are inactivated by protein phosphatase 2A, Rattus norvegicus"
xref: Reactome:REACT_89253 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Mus musculus"
xref: Reactome:REACT_92068 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Xenopus tropicalis"
xref: Reactome:REACT_92797 "AMPK is dephosphorylated, Xenopus tropicalis"
xref: Reactome:REACT_93522 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Drosophila melanogaster"
xref: Reactome:REACT_93551 "PHLPP dephosphorylates S473 in AKT, Mus musculus"
xref: Reactome:REACT_93922 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Bos taurus"
xref: Reactome:REACT_94309 "ERKs are inactivated by protein phosphatase 2A, Drosophila melanogaster"
xref: Reactome:REACT_94590 "ERKs are inactivated by protein phosphatase 2A, Canis familiaris"
xref: Reactome:REACT_94855 "PHLPP dephosphorylates S473 in AKT, Canis familiaris"
xref: Reactome:REACT_95676 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Canis familiaris"
xref: Reactome:REACT_96055 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Danio rerio"
xref: Reactome:REACT_96980 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Mus musculus"
xref: Reactome:REACT_98890 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Gallus gallus"
is_a: GO:0004721 ! phosphoprotein phosphatase activity
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